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Prof. M. Vijayalakshmi

 

 

Systems Biology- Fundamentals- gene expression paradigms - genetic switch in Lambda Phage -Noise-based Switches and Amplifiers for Gene Expression -Ecoli chemotaxis - genetic oscillators - Noise in Biochemical Systems-Quorum Sensing - Programmed Population Control by Cell-Cell Communication and Regulated Killing- Drosophila Development - Establishment of Developmental Precision and Proportions in the Early Drosophila embryo -Gene expression networks -Gene regulation at a single cell level-Transcription Networks basic concepts

 

Sl. No

Topics

Hours

Module

1.

Systems Biology – Fundamentals

  • Overview of Gene Control –Working of Genetic Switches – Introductory Systems Biology The biochemical paradigm, genetic paradigm and the systems paradigm.

5

Module 1

2.

Kinetics

  • Equilibrium Binding and Co-operativity -Michaelis-Menten Kinetics –identical and independent binding sites – Identical and interacting binding sites, non-interacting binding sites.

  • Genetic switch in Lambda Phage -Noise-based Switches and Amplifiers for Gene Expression.

  • Synthetic genetic switches –Ecoli chemotaxis –biological oscillators- genetic oscillators -The Origin and Consequences of Noise in Biochemical Systems.

15

6

 

4

 

5

Module 2

3.

Developmental Systems Biology

  • Building an Organism Starting From a Single Cell -Quorum Sensing – Programmed Population Control by Cell-Cell Communication and Regulated Killing- Drosophila Development.

  • Establishment of Developmental Precision and Proportions in the Early Drosophila embryo.

8

5

 

3

Module 3

4.

Gene expression networks

  • Gene regulation at a single cell level- Transcription Networks  -basic concepts -coherent Feed Forward Loop (FFL) and delay gate -The incoherent FFL -Temporal order, Signaling networks and neuron circuits -Aspects of multi-stability in gene networks.

14

 

Module 4

 

Total

42