Print

Prof. S. Swaminathan

 

 

This course helps the learners to understand thoroughly the key concepts of tissue organization, remodeling and strategies for restoration of tissue function. This will enable them to design tissue regeneration and tissue injury repair strategies.

 

Sl. No

Course content

Duration (in hours)

Module

1.

Introduction to tissue engineering, Cells as therapeutic Agents with examples, Cell numbers and growth rates.

2

Module 1

2.

Tissue organization, Tissue Components, Tissue types, Functional subunits. Tissue Dynamics, Dynamic states of tissues, Homeostasis in highly prolific tissues and Tissue repair. Angiogenesis.

3

 Module 2

3.

Cellular fate processes, Cell differentiation, Cell migration - underlying biochemical process.

3

 Module 3

4.

Cell division - mitotic cell cycle, Cell death - biological description of apoptosis.

3

 Module 4

5.

Coordination of cellular fate processes - soluble signals, types of growth factors and chemokines, sending and receiving a signal, processing a signal, integrated responses, soluble growth factor receptors, Malfunctions in soluble signaling.

3

 Module 5

6.

Cell-extracellular matrix interactions - Binding to the ECM, Modifying the ECM, Malfunctions in ECM signaling.

Direct Cell-Cell contact - Cell junctions in tissues, malfunctions in direct cell-cell contact signaling. Response to mechanical stimuli.

3

 Module 6

7.

Measurement of cell characteristics - cell morphology, cell number and viability, cell-fate processes, cell motility, cell function.

2

 Module 7

8.

Cell and tissue culture - types of tissue culture, media, culture environment and maintenance of cells in vitro, cryopreservation.

3

 Module 8

9.

Basis for Cell Separation, characterization of cell separation, methods of cell separation.

3

 Module 9

10.

Biomaterials in tissue engineering - biodegradable polymers and polymer scaffold processing.

3

 Module 10

11.

Growth factor delivery, Stem cells.

3

Module 11

12.

Gene therapy.

1

Module 12

13.

Bioreactors for Tissue Engineering.

1

Module 13

14.

In vivo cell & tissue engineering case studies: Artificial skin, Artificial blood vessels.

3

Module 14

15.

In vivo cell & tissue engineering case studies: Artificial pancreas, Artificial liver.

3

Module 15

16.

In vivo cell & tissue engineering case studies: Regeneration of bone, muscle.

3

Module 16

17.

In vivo cell & tissue engineering case studies: Nerve regeneration.

3

Module 17
 

Total

45