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Dr. K. UMA MAHESWARI

Name: Dr. K. UMA MAHESWARI

Designation: Professor & Associate Dean  

Position: Chemistry, Bioengineering & Pharmacy

               School of Chemical & biotechnology

               SASTRA University.

Teaching Experience: 10 years

Educational Qualifications / Training

Degree

Major(s) 

Year of  

passing 

College

University

Ph.D.

Applied Chemistry

2000

PSG College of Technology, Coimbatore

Bharathiar University, Coimbatore.

M.Sc.

Applied Chemistry

1995

Government College of Technology, Coimbatore

Bharathiar University, Coimbatore

 

 

B.Sc.

Chemistry, Physics

Anci: Maths, Biochemistry

1993

Avinashilingam Institute for Home Science & Higher Education for Women, Coimbatore

 

Avinashilingam Deemed University, Coimbatore

Research training

Thin film processing, Clean room processes

 

2005

High Density Electronics Center, Fayetteville, USA

University of Arkansas, USA

Post Doctoral Research

Electro-physiology

2002

University of Texas Southwestern Medical Center, Dallas,  USA

 

University of Texas, USA

 

List of Publications:

  1. Priyadharshini Kumaraswamy. Rajesh Lakshmanan, Swaminathan Sethuraman, Uma Maheswari Krishnan, Self Assembly of Peptides: Influence of Substrate, pH and Medium on the Formation of Supramolecular Assemblies, Soft Matter, DOI:10.1039/C0SM00897D (in press)
  1. Anuradha Subramanian, Uma Maheswari Krishnan, Swaminathan Sethuraman, Fabrication of uniaxially aligned 3-D electrospun scaffolds for neural regeneration, Biomedical Materials (in press)
  1. Harit Mohan, K. Uma Maheswari, Amal K Bera, G.K Suraishkumar, Reactive Oxygen Species Mediated Modifications in Bacillus subtilis Lipid Membrane to Improve Protein Productivities, Process Biochemistry, 45 (2010) 467–474,
  1. Dhandayuthapani B, Krishnan UM, Sethuraman S.  Fabrication & Characterization of Chitosan–Gelatin Blend Nanofibers for Skin Tissue Engineering. Journal of Biomedical Materials Research: Part B, 2010 (Accepted)
  1. Mitra M, Kandalam M, Krishnan UM, Krishnakumar S, Small Interfering RNA-mediated down-regulation of Ep-CAM decreases proliferation potential of retinoblastoma Y79 cell line in vitro, Molecular Vision, 2010 (Accepted
  1. Durga Janani Sivalingam, Sakthivel Gandhi, Sridharan Madhanaguruswamy, Rajan Kalpoondi Sekhar, Uma Maheswari Krishnan, John Bosco Balaguru Rayappan, Nanostructured ZnO thin films for food quality discrimination, International Journal of Nanoscience (in press)
  1. Ramana, L.N., Sethuraman, S., Ranga, U., Krishnan, U.M, Development of a liposomal nanodelivery system for nevirapine, Journal of Biomedical Science 17 (1), 2010,
  1. Krishnan, S., Lakshmanan, S., Iyer, G.K., UmaMaheswari, K., Krishnakumar, S, The role of signaling pathways in the expansion of corneal epithelial cells in serum-free B27 supplemented medium, Molecular Vision 16, 2010, pp. 1169-1177
  1. Dhandayuthapani B, Krishnan UM, Sethuraman S.  Fabrication & Characterization of Chitosan–Gelatin Blend Nanofibers for Skin Tissue Engineering. Journal of Biomedical Materials Research - Part B Applied Biomaterials 94 (1), pp. 264-272
  1. Mitra, M., Kandalam, M., Verma, R.S., Uma Maheswari, K., Krishnakumar, S, Genome-wide changes accompanying the knockdown of Ep-CAM in retinoblastoma, Molecular Vision 16, 2010, pp. 828-842
  1. Gandhi, S., Sethuraman, S., Krishnan, U.M, Influence of polyhydric solvents on the catalytic & adsorption properties of self-oriented mesoporous SBA-15 silica, Journal of Porous Materials, 2010, pp. 1-8
  1. Subramanian A, Krishnan UM, Sethuraman S.  Development of Biomaterial Scaffold for Nerve Tissue Engineering: Biomaterial Mediated Neural Regeneration, Journal of Biomedical Science, 2009, 16: 108. (DOI: 10.1186/1423-0127-16-108)
  1. K. Uma Maheswari, Lipid bilayer-methotrexate interactions: The basis of methotrexate neurotoxicity, Current Science, 81 (5), Sept. 2001, 571-574.
  1. K. U Maheswari, T. Ramachandran, Dr. Rajaji, Interaction of cisplatin with planar model membranes – Dose dependent change in electrical characteristics, Biochimica et Biophysica Acta, 1463, 2000, 230-240.

 

List of books/ reviews written

  1. Skin Tissue Engineering.  Anuradha Subramanian, Uma Maheswari Krishnan, Swaminathan Sethuraman. In Electrospinning for Tissue Regeneration.  Eds: Bosworth & Downes.  Woodhead Publishing Limited, Cambridge, 2011.
  1. Anuradha Subramanian, Kirthanashri Srinivasan Vasanthan, Uma Maheswari Krishnan, Swaminathan Sethuraman.  Chitosan and its derivatives in clinical use & applications.  In: Biodegradable Polymers in Clinical Use and Clinical Development.  Eds: Avi Domb, Neeraj Kumar, Aviva Azra. John Wiley & Sons, USA, 2011.

 

Invited Lectures

  • Nanobiotechnology: Current perspectives & Future Scope, Abeda Inamdar College, October 2009
  • Medical Nanotechnology: Promises & Challenges, Symposium on Nanomaterials & their Applications, Fergusson College, Pune, March 2009
  • Nanobiotechnology: New Frontiers for Healthcare & Industry, Birla Institute of Technology, Kalyan, February 2009
  • Nano drug delivery systems, Indo-French workshop in Nanotechnology for Biomedical Applications, Paris, France, November 2008
  • Biomaterials, National Institute of Technology, Trichy, February 2008
  • Prospects in Nanotechnology, Srinivasa Ramanujan Centre, Kumbakonam, January 2008

 

Details of Research Projects:

S. No. 

Title of Project 

Funding 

Agency 

Amount 

(in lakhs) 

Date of Sanction and Duration 

1.

A Study of Anti-oxidant/ pro-oxidant properties of flavonoids in presence of transition metal ions using planar lipid Bilayers

Science, Engineering & Research Council, DST

 

19.57

 

2.8.2006

(2 years)

2.

Studies  of the interaction of Polymeric alkyl pyridinium salts    (Poly-APS) from marine sponge toxins with planar lipid Bilayers

Fast track Scheme for Young Scientists, DST

 

19.86

 

14.9.2006

(3 years)

 

3.

Development of a novel free radical biosensor based on embedded system

DST, Technology Development Board

15.79

29.12.2008

(18 months)

4.

Development of stealth nanoimmunoliposomes for si-RNA delivery against EpCAM expressing epithelial cancers (in collaboration with Vision Research Centre, Sankara Nethralaya)

DBT

71.3

13.8.2009

(3 years)

5.

Targeted delivery of stealth immunoliposomes for antiretroviral therapy

ICMR

32.0

March 2010

(3 years)

*awaiting release of funds

6.

Targeted nanocarriers for suicide gene therapy

ICMR

65.0

April 2010

(3 years)

*awaiting release of funds