1.

Systems Biology – Fundamentals

• Overview of Gene Control –Working of Genetic Switches – Introductory Systems Biology The biochemical paradigm, genetic paradigm and the systems paradigm.

5

Module 1

2.

Kinetics

• Equilibrium Binding and Co-operativity -Michaelis-Menten Kinetics –identical and independent binding sites – Identical and interacting binding sites, non-interacting binding sites.

• Genetic switch in Lambda Phage -Noise-based Switches and Amplifiers for Gene Expression.

• Synthetic genetic switches –Ecoli chemotaxis –biological oscillators- genetic oscillators -The Origin and Consequences of Noise in Biochemical Systems.

15

6

4

5

Module 2

3.

Developmental Systems Biology

• Building an Organism Starting From a Single Cell -Quorum Sensing – Programmed Population Control by Cell-Cell Communication and Regulated Killing- Drosophila Development.

• Establishment of Developmental Precision and Proportions in the Early Drosophila embryo.

8

5

3

Module 3

4.

Gene expression networks

• Gene regulation at a single cell level- Transcription Networks  -basic concepts -coherent Feed Forward Loop (FFL) and delay gate -The incoherent FFL -Temporal order, Signaling networks and neuron circuits -Aspects of multi-stability in gene networks.

14

Module 4

Total

42